ing study involves oral dosing of male rats for 10
days followed by an 84-day recovery period. The
study determined total organic fluorine levels in
plasma, liver, and fat. It provides a screening
measure of what toxicologists refer to as bioup-
take and bioclearance. The AUCINF, or area under
the curve integrated to infinity, provides a relative
integrated measure of the absorbed dose of the
compound studied. A compound that is absorbed
and quickly eliminated or is simply not absorbed
will have a low relative AUCINF. It is very clear
from Figure 2 that the 6:2 FtS, the C6 acid
(PFHxA), and the two commer-
cial fluorotelomer-based fire
fighting surfactants have
extremely low values when
compared to PFOS. In this study,
PFOA is also lower when
compared to PFOS.
PFOA global stewardship
program
Although they are not made
with PFCAs, fluorotelomer-based
fluorosurfactants may contain
trace levels of PFOA. Fluoro-
telomer producers are working
toward the elimination of trace
levels of PFOA, PFOA precursors,
and related higher homologue
chemicals from finished products
by 2015 as part of the US
EPA global stewardship pro-
gram. Under the program, EPA
asked fluorotelomer producers to make two
commitments:
Reduce by 95% by 2010 (based on a 2000 year
baseline) facility emissions and product content
levels of PFOA, precursor chemicals that can
break down to PFOA, and related higher
homologue chemicals.
Commit to working towards elimination of
PFOA, precursor chemicals that can break down
to PFOA, and related higher homologue chemi-
cals from emissions and products by 2015.
The recent announcements by fluorochemical
32 INTERNATIONAL FIRE PROTECTION
Figure 2. Biopersistence
Screening Study Results
FIRE FIGHTING FOAM COALITION
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